Research advances in endoplasmic reticulum stress in methamphetamine use disorder
10.3969/j.issn.1671-8348.2024.01.027
- VernacularTitle:内质网应激在甲基苯丙胺使用障碍中的研究进展
- Author:
Tao WEI
1
,
2
;
Dongliang JIAO
Author Information
1. 蚌埠医学院精神卫生学院,安徽蚌埠 233030
2. 淮南市第一人民医院护理部,安徽淮南 232007
- Keywords:
methamphetamine;
neurotoxicity;
endoplasmic reticulum stress;
unfolded protein response;
apoptosis;
review
- From:
Chongqing Medicine
2024;53(1):139-144
- CountryChina
- Language:Chinese
-
Abstract:
Methamphetamine use disorder is an ongoing global public health problem with complex mechanisms involving multiple neural circuits and neurotransmitters in the brain,and there are currently no effective drugs and methods to treat it.This article reviews the role of endoplasmic reticulum stress in meth-amphetamine use disorder and discusses the treatment strategies that can be used to mitigate the methamphet-amine-induced neurotoxic damage,which will contribute to the exploration of methamphetamine use disorder mechanisms and the development of new target drugs.
