Correlation analysis of ICAM-1 and NF-κB expression with hepatic inflammatory activity and degree of fibrosis in liver tissues of chronic hepatitis B patients
10.3969/j.issn.1671-8348.2024.01.020
- VernacularTitle:慢性乙型肝炎患者肝组织中ICAM-1、NF-κB表达与肝脏炎症活动度及纤维化程度的相关性分析
- Author:
Tao LI
1
;
Rilin LI
;
Zongshu XIE
;
Xiuzhen YANG
;
Dongming SHE
;
Zhijuan LIU
;
Shufang YUAN
Author Information
1. 桂林医学院,广西桂林 541004
- Keywords:
intercellular adhesion molecule-1;
nuclear factor kappa-B;
chronic hepatitis B
- From:
Chongqing Medicine
2024;53(1):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of intercellular adhesion molecule-1(ICAM-1)and nu-clear factor(NF)-κB in hepatic tissues of the patients with chronic hepatitis B,and to analyze their correlation with the hepatic inflammatory activity and fibrosis degree.Methods The liver biopsy specimens from 66 pa-tients with hepatitis B and 10 non-hepatopathic controls were selected,and immunohistochemistry and in situ hybridization were used to detect ICAM-1 and NF-κB expression levels in different liver tissues.Results The positive rate of ICAM-1 and NF-κB expression in liver tissues of the patients with chronic hepatitis B was higher than that in normal liver tissues,and the difference was statistically significant(P＜0.05).The expres-sion of ICAM-1 and NF-κB in the patients with hepatitis B was positively correlated with the inflammatory ac-tivity and fibrosis degree(r=0.493,0.496,P＜0.01;r=0.580,0.519,P＜0.01).Conclusion ICAM-1 and NF-κB in the patients with chronic hepatitis B are highly expressed,which is useful in judging the hepatic in-flammatory activity and fibrosis degree.
