Research progress of lipoprotein a in cardiovascular diseases
10.3969/j.issn.1671-8348.2023.23.023
- VernacularTitle:脂蛋白a在心血管疾病中的研究进展
- Author:
Guoli YANG
1
;
Min MAO
;
Bao YANG
;
Yue LUO
;
Fan WU
;
Kanghua MA
Author Information
1. 重庆医科大学附属第一医院心血管内科,重庆 400016
- Keywords:
lipoprotein a;
cardiovascular diseases;
diabetes mellitus;
proprotein convertase subtilisin/kexin type 9;
antisense oligonucleotides;
review
- From:
Chongqing Medicine
2023;52(23):3648-3652
- CountryChina
- Language:Chinese
-
Abstract:
Lipoprotein a[Lp(a)]is a risk factor for cardiovascular disease.This paper summarizes the structure,anabolism and mechanism of action of Lp(a),and the relationship between Lp(a)and cardiovascular diseases,liver and kidney diseases,diabetes mellitus and other diseases.It focuses on the traditional lipid-low-ering regimen to reduce plasma Lp(a)level and the current popular novel therapies,such as mipomersen,pel-acarsen,olpasiran,and the interfering effect of related drugs on Lp(a)level and the degree of benefit on cardi-ovascular events.How to reduce plasma Lp(a)level and improve patient prognosis will be the key to future Lp(a)related research.
