Diagnosis and treatment progress of liver injury after allogeneic hematopoietic stem cell transplantation

VernacularTitle:异基因造血干细胞移植术后肝损伤的诊治进展
Author: Jingsong WU ¹ ; Xinyou ZHANG ; Jihao ZHOU
Author Information

1. 暨南大学第二临床医学院，深圳　518000
Keywords: Hematopoietic stem cell transplantation; Liver injury; Sinusoidal obstruction syndrome; Graft vs host disease; Infection
From: Journal of Leukemia & Lymphoma 2024;33(3):189-192
CountryChina
Language:Chinese
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative method for various hematological diseases. With the optimization of transplantation technology, the clinical application of allo-HSCT is more and more mature. Post-transplant liver injury is one of the common postoperative complications, which seriously affects the quality of life and long-term survival of patients. The causes of liver injury after allo-HSCT can be divided into non-infectious and infectious factors, which show similar clinical manifestations and different treatment principles. Timely diagnosis of post-transplant liver injury and the identification of the disease cause will be beneficial for early prevention or targeted treatment, thereby improving patients' prognosis. This review focuses on the etiology, clinical features, and treatment options of liver injury after allo-HSCT, aiming to deepen the understanding of hematologists on liver injury after allo-HSCT.