Advances in the application of single-cell sequencing technology in diagnosis and prognostic assessment of acute leukemia

VernacularTitle:单细胞测序技术在急性白血病诊断和预后评估中的应用进展
Author: Xiaotong CHEN ¹ ; Mengping XI ; Yingjun CHANG
Author Information

1. 北京大学人民医院血液科　北京大学血液病研究所　国家血液系统疾病临床医学研究中心　造血干细胞移植治疗血液病北京市重点实验室，北京　100044
Keywords: Leukemia, acute; Single-cell sequencing; Diagnosis; Prognosis evaluation
From: Journal of Leukemia & Lymphoma 2024;33(1):20-24
CountryChina
Language:Chinese
Abstract: Currently, single-cell multi-omics technologies including single-cell DNA sequencing (scDNA-seq) and single-cell RNA sequencing (scRNA-seq) have been used to reveal the heterogeneity of malignant tumor cells, elucidate their pathogenesis, drug resistance and recurrence mechanisms, which provide new strategies for the diagnosis and prognostic assessment of malignant tumors. This article reviews the application of single-cell sequencing technology in the diagnosis and prognostic assessment of acute leukemia based on the progress reported at the 65th American Society of Hematology Annual Meeting.