Research progress in etiology and pathogenesis of polycystic ovary syndrome
10.13481/j.1671-587X.20240136
- VernacularTitle:多囊卵巢综合征病因及其发病机制的研究进展
- Author:
Yajie GE
1
;
Wen XU
;
Shimin GUAN
;
Lina WANG
Author Information
1. 吉林大学第一医院妇产科中心,吉林 长春 130021
- Keywords:
Polycystic ovary syndrome;
Endocrine metabolic disorder;
Gut microbiome;
Inflammation;
Environment;
Genetics
- From:
Journal of Jilin University(Medicine Edition)
2024;50(1):288-294
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome(PCOS)is a heterogeneous disorder closely associated with reproductive endocrine dysfunction in the women.The etiology and pathogenesis of PCOS remain unclear.PCOS is the result of the combination of endocrine metabolic disorders,genetics,and environmental factors.Hyperandrogenemia(HA)and insulin resistance(IR)are the fundamental pathophysiological changes in the development of PCOS,and their interactions exacerbate the clinical manifestations of the PCOS patients.The family aggregation and twin study results confirm the genetic predisposition of PCOS;the genome-wide association study(GWAS)results confirm some risk loci and candidate genes of PCOS.The unhealthy lifestyle habits and environmental endocrine disruptors also play an important role in the progression of PCOS,and the gut microbita is involved in the pathogenesis of PCOS.This article provides a comprehensively retrospective analysis on the recent studies about PCOS,and reviews both internal factors and external factors related to the etiology and pathogenesis of PCOS.
