Bionic design,preparation and clinical translation of oral hard tissue restorative materials
10.19723/j.issn.1671-167X.2024.01.002
- VernacularTitle:口腔硬组织修复材料仿生设计制备和临床转化
- Author:
Han ZHAO
1
;
Yan WEI
;
Xuehui ZHANG
;
Xiaoping YANG
;
Qing CAI
;
Chengyun NING
;
Mingming XU
;
Wenwen LIU
;
Ying HUANG
;
Ying HE
;
Yaru GUO
;
Shengjie JIANG
;
Yunyang BAI
;
Yujia WU
;
Yusi GUO
;
Xiaona ZHENG
;
Wenjing LI
;
Xuliang DENG
Author Information
1. 北京大学口腔医学院·口腔医院综合科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,国家药品监督管理局口腔材料重点实验室,北京 100081
- Keywords:
Dental restoration materials;
Guided bone regeneration membranes;
Electrical microenvi-ronment;
Bone filling materials;
Biomechanics
- From:
Journal of Peking University(Health Sciences)
2024;56(1):4-8
- CountryChina
- Language:Chinese
-
Abstract:
Oral diseases concern almost every individual and are a serious health risk to the popula-tion.The restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the contour.Based on the principle of"learning from the nature",Deng Xu-liang's group of Peking University School and Hospital of Stomatology has proposed a new concept of"microstructural biomimetic design and tissue adaptation of tooth/jaw materials"to address the worldwide problems of difficulty in treating dentine hypersensitivity,poor prognosis of restoration of tooth defects,and vertical bone augmentation of alveolar bone after tooth loss.The group has broken through the bottle-neck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects,and invented key technologies such as crystalline/amorphous multi-level assembly,ion-transportation blocking,and multi-physical properties of the micro-environment reconstruction,etc.The group also pioneered the cationic-hydrogel desensitizer,digital stump and core integrated restora-tions,and developed new crown and bridge restorative materials,gradient functionalisation guided tissue regeneration membrane,and electrically responsive alveolar bone augmentation restorative membranes,etc.These products have established new clinical strategies for tooth/jaw defect repair and achieved inno-vative results.In conclusion,the research results of our group have strongly supported the theoretical im-provement of stomatology,developed the technical system of oral hard tissue restoration,innovated the clinical treatment strategy,and led the progress of the stomatology industry.
