Correlation between UGRP1 and apoptosis pathway mediated by Fas in hashimoto thyroiditis

VernacularTitle:桥本甲状腺炎UGRP1与Fas介导的凋亡通路的相关性研究
Author: Shanshan MA ¹ ; Yue WU ; Li ZHU ; Chenyang LU ; Chunlin ZUO
Author Information

1. 安徽医科大学第一附属医院内分泌科,合肥 230022
Keywords: uterine globulin associated protein 1; Fas/FasL pathway; hashimoto thyroiditis
From: Acta Universitatis Medicinalis Anhui 2024;59(2):289-292
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between uterine globulin associated protein 1(UGRP1)and Fas mediated apoptosis pathway in hashimoto thyroiditis(HT).Methods The expression of UGRP1 in thyroid cells of normal people and HT patients was detected by immunohistochemistry(IHC).FRTL-5 cells were transfect-ed by plasmids in vitro,and control group,UGRP1 group,Fas group were established respectively.Real-time fluo-rescent quantitative reverse transcription PCR(RT-qPCR)was used to detect the expression of Fas and UGRP1 mRNA in each group.Results UGRP1 expression was positive in thyroid cells of HT patients and negative in that of normal people.There were no significant differences between control group and UGRP1 group in Fas gene ex-pression(1.085 0±0.124 9 vs 1.021 0±0.113 9).Compared with the control group,the expression of UGRP1 gene increased significantly in Fas group(P＜0.000 1,5.807 0±0.323 2 vs 0.752 7±0.076 0).Conclusion The high expression of UGRP1 in HT may be related to apoptosis pathway mediated by Fas.