Effects of Porphyromonas gingivalis infection and vitamin D pathway protein expression on survival and prognosis of patients with esophageal squamous cell carcinoma
10.19405/j.cnki.issn1000-1492.2023.12.006
- VernacularTitle:牙龈卟啉单胞菌感染及维生素D通路蛋白表达对食管鳞癌患者生存预后的影响
- Author:
Mengfan QIAN
1
;
Jinyu KONG
;
Yiwen LIU
;
Wei SUN
;
Fuyou ZHOU
;
Shegan GAO
Author Information
1. 河南科技大学临床医学院,河南科技大学第一附属医院,河南科技大学肿瘤研究所,河南省肿瘤表观遗传重点实验室,河南省微生态与食管癌防治重点实验室,洛阳 471003
- Keywords:
esophageal squamous cell carcinoma;
Porphyromonas gingivalis;
CYP24A1;
CYP27B1;
vitamin D receptor;
prognosis
- From:
Acta Universitatis Medicinalis Anhui
2023;58(12):2024-2031
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of Porphyromonas gingivalis(Pg)infection and expression of vitamin D pathway-related proteins on the survival and prognosis of patients with esophageal squamous cell carcinoma(ES-CC).Methods Pg infection and the expression of 24 hydroxylase(CYP24A1),1α hydroxylase(CYP27B1)and vitamin D receptor(VDR)in 173 ESCC tissues were detected by immunohistochemistry.The correlation between each index and the survival time of patients was analyzed.Results The positive rates of Pg,CYP24A1,CYP27B1 and VDR in ESCC were 43.35％,37.57％,20.23％and 21.97％,respectively.The 5-year survival time of ES-CC patients in the Pg+CYP24A1+CYP27B-VDR-high-risk group was shortened(P＜0.05).Conclusion Pg infection and vitamin D pathway-associated proteins can be used as reliable indicators to predict the survival and prognosis of ESCC patients.
