GLUT1-targeted Nano-delivery System for Active Ingredients of Traditional Chinese Medicine：A Review
10.13422/j.cnki.syfjx.20240665
- VernacularTitle:GLUT1靶向型中药活性成分纳米递送系统的研究进展
- Author:
Hua ZHU
1
;
Huimin LUO
1
;
Si LIN
2
;
Bingbing WANG
1
;
Jinwei LI
1
;
Liba XU
1
;
Miao ZHANG
1
;
Fengfeng XIE
1
;
Long CHEN
1
;
Meilin LI
1
;
Lu LU
1
Author Information
1. Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine，Guangxi Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine，Guangxi Zhuang Autonomous Region Ethnic Medicine Resources and Application Research Center of Engineering， Guangxi University of Chinese Medicine，Nanning 530200，China
2. The Second Affiliated Hospital of Guangxi Medical University，Nanning 530007，China
- Publication Type:Journal Article
- Keywords:
glucose transporter protein 1（GLUT1）;
targeting;
drug delivery system;
Warburg effect;
tumor microenvironment;
high-permeability long retention effect;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(12):270-280
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells use glycolysis to provide material and energy under hypoxic conditions to meet the energy requirements for rapid growth and proliferation， namely the Warburg effect. Even under aerobic conditions， tumor cells mainly rely on glycolysis to provide energy. Therefore， glucose transporter protein 1（GLUT1）， which is involved in the process of glucose metabolism， plays an important role in tumorigenesis， development and drug resistance， and is considered to be one of the important targets in the treatment of malignant tumors. In recent years， research on tumor glucose metabolism has gradually become a hot spot. It has been shown that various factors are involved in the regulation of tumor energy metabolism， among which the role of GLUT1 is the most critical. In this paper， the authors reviewed the latest research progress of GLUT1-targeted traditional Chinese medicine（TCM） active ingredient nano-delivery system in tumor therapy， aiming to reveal the feasibility and effectiveness of this system in the delivery of chemotherapeutic drugs. The GLUT1-targeted TCM active ingredient nano-delivery system can overcome the bottleneck of the traditional targeting strategy as well as the high-permeability long retention（EPR） effect. In summary， the authors believe that the GLUT1-targeted TCM active ingredient nano-delivery system provides a new strategy for targeted treatment of tumors and has a broad application prospect in tumor prevention and treatment.
