Feasibility of Tetramethylpyrazine in Prevention and Treatment of Alzheimer's Disease Based on Theory of 'Toxin Damaging Brain Collaterals'
10.13422/j.cnki.syfjx.20240509
- VernacularTitle:基于“毒损脑络”理论探讨川芎嗪防治阿尔茨海默病的可行性
- Author:
Jianing YIN
1
;
Xitong ZHAO
1
;
Wenqian FAN
1
;
Baojian DU
1
;
Fang FANG
1
;
Jun GUAN
1
Author Information
1. School of Chinese Materia，Beijing University of Chinese Medicine，Beijing 100029，China
- Publication Type:Journal Article
- Keywords:
toxin damaging brain collaterals;
blood stasis;
tetramethylpyrazine;
Alzheimer's disease;
pharmacological effects;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(12):209-218
- CountryChina
- Language:Chinese
-
Abstract:
With intensified aging， Alzheimer's disease has become a serious problem in China's health field. In the field of traditional Chinese medicine （TCM）， Alzheimer's disease mainly describes cognitive deficits such as dementia and amnesia. After the inheritance and summary by medical experts of successive generations， the theory of "toxin damaging brain collaterals" has become a mature pathogenesis hypothesis of this disease. Blood stasis， as one of the main viral pathogens， is also closely related to the theory of Alzheimer's disease in modern pharmacology. Chuanxiong Rhizoma is used frequently in clinical prescriptions for Alzheimer's disease. As the main component of Chuanxiong Rhizoma， tetramethylpyrazine has a series of pharmacological effects on the cardiovascular system such as vasodilation， anti-platelet aggregation， anti-atherosclerosis， and anti-myocardial ischemia， which reflects the effects of Chuanxiong Rhizoma in activating blood circulation and removing blood stasis. However， few studies have focused on the effect of tetramethylpyrazine on the pathogenesis of Alzheimer's disease. From the perspective of TCM theory and modern pharmacology， this article discussed the effects of tetramethylpyrazine on the pathology and pathogenesis of Alzheimer's disease from the aspects of cardiovascular function， oxidative stress， inflammatory response， mitochondrial function， and cholinergic system and made prospects for the future application of tetramethylpyrazine to prevent and treat Alzheimer's disease.
