Effects of dexmedetomidine-assisted general anesthesia on the hemodynamics and cognitive function in elderly patients undergoing painless enteroscopy
- VernacularTitle:右美托咪定辅助全身麻醉对老年无痛肠镜检查患者血流动力学及认知功能的影响
- Author:
Junli LI
1
;
Nannan LIU
1
;
Xiaoying LU
1
Author Information
1. Dept. of Anesthesiology，the Second People’s Hospital of Jiaozuo，Henan Jiaozuo 454100，China
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
elderly patient;
painless enteroscopy;
hemodynamics;
cognitive function;
general anesthesia
- From:
China Pharmacy
2024;35(9):1129-1132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effects of dexmedetomidine （DEX）-assisted general anesthesia on hemodynamics and cognitive function in elderly patients undergoing painless enteroscopy. METHODS From July 2020 to February 2022， 180 elderly patients undergoing painless enteroscopy in the outpatient operating room of the Second People’s Hospital of Jiaozuo were selected and divided into a control group （n＝90） and an observation group （n＝90） according to the random number table method. The control group was given routine general anesthesia （induced with sufentanil and propofol anesthesia， maintained with propofol anesthesia）， while the observation group was given DEX-assisted general anesthesia after preoperative preparation. The hemodynamic indexes [mean arterial pressure （MAP）， heart rate （HR）]， dosage of general anesthesia， awakening time， cognitive function [minimized mental status examination （MMSE）]， and the incidence of adverse drug reactions were compared between the two groups. RESULTS There was no significant difference in various indicators before anesthesia （T0） between 2 groups （P＞ 0.05）. Compared with T0， MAP and HR of the two groups were reduced significantly 10 minutes after anesthesia （T1）， at the time of enteroscope reaching the ileum and cecum （T2）， enteroscope withdrawal after the examination （T3）， and 10 minutes after surgery （T4）； but MAP and HR of the observation group at T1， T2， T3， and T4 were all higher than those of the control group （P＜0.05）. Compared with the control group， the dosage of general anesthesia and the recovery time in the observation group were significantly reduced or shortened， the MMSE scores at 1， 2 and 3 days after the operation were significantly increased， while the incidence of cognitive dysfunction and adverse reactions were significantly reduced （P＜0.05）. CONCLUSIONS DEX can effectively improve the hemodynamics and cognitive function of elderly patients undergoing painless enteroscopy， which is beneficial to reduce the dosage of general anesthesia， shorten recovery time， and has better safety.
