Research progress of integrated stress response in central nervous system diseases
10.11665/j.issn.1000-5048.2023112302
- VernacularTitle:整合应激反应在中枢神经系统疾病中的研究进展
- Author:
Aili LAN
1
;
Gang LIU
;
Chaoran WU
;
Hong LIAO
Author Information
1. 中国药科大学新药筛选与药效评价中心
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease / ischemic stroke / traumatic brain injury / integrated stress response / modulators of integrated stress
- From:
Journal of China Pharmaceutical University
2024;55(2):194-201
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Integrated stress response is an adaptive response produced by eukaryotic cells after intracellular and extracellular stimulation. The activation of integrated stress response inhibits the translation of most proteins, yet it can promote the translation of certain proteins to cope with complex cellular microenvironment changes. A large number of studies have found that in a variety of nervous system diseases, the integrated stress response can be activated by stress signals of disease-related cells and participates in the occurrence and progression of diseases through processes such as learning and memory consolidation, myelin regeneration and synaptic plasticity. This article summarizes the role, mechanism and possible drug targets of integrated stress response in central nervous system diseases and discusses the potential of pharmacological methods to regulate integrated stress response in the treatment of central nervous system diseases, in order to provide reference for pathological research on and drug development for central nervous system diseases.
