Recent advances in bioactivity evaluation methods of uric acid-lowering compounds
10.11665/j.issn.1000-5048.2023080103
- VernacularTitle:降尿酸化合物的活性评价方法研究进展
- Author:
Danhui QI
1
;
Xiaoyu SHI
;
Xinyong LIU
;
Peng ZHAN
Author Information
1. 山东大学药学院药物化学研究所
- Publication Type:Journal Article
- Keywords:
hyperuricemia / gout / uric acid lowering / activity evaluation / drug discovery
- From:
Journal of China Pharmaceutical University
2024;55(2):167-180
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Hyperuricemia is a metabolic disease caused by elevated uric acid in the body, and is closely related to the increased risk of cardiovascular disease, metabolic disorders, and renal complications. In the development process of uric acid-lowering drugs, activity evaluation is a crucial step. At present, the activity screening methods of uric acid-lowering drugs can be roughly divided into two categories: in vitro and in vivo. In vitro screening is mainly for such targets as xanthine oxidase, urate transporters, and purine nucleoside phosphorylase, etc.; while in vivo screening is achieved by rodent, poultry and organoid models. In this article, the activity evaluation methods for uric acid-lowering compounds are comprehensively summarized both in vitro and in vivo, aiming to provide some insight for the development of uric acid-lowering drugs.
