Research progress on targeted protein S-palmitoylation modification in T cell immunotherapy
10.11665/j.issn.1000-5048.2023112903
- VernacularTitle:靶向蛋白S-棕榈酰化修饰在T细胞免疫疗法中的研究进展
- Author:
Liting SUN
1
;
Weiguo ZHANG
;
Yue TONG
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
S-palmitoylation / DHHC / T cells / immunotherapy / peptide inhibitors
- From:
Journal of China Pharmaceutical University
2024;55(1):45-52
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: S-palmitoylation, a reversible and dynamic post-translational modification in cells, is involved in regulating the transcription and expression of downstream target genes as well as signal transduction, thereby affecting cell life activities. Studies have shown that thousands of human proteins undergo S-palmitoylation modification, suggesting that S-palmitoylation is closely related to the progression and treatment of diseases. T cells play central roles in anti-tumor immune responses. A variety of T cell immune-related proteins are regulated by S-palmitoylation. In the present study, we focus on the impact of S-palmitoylation on T cell signal transduction and its application in T cell immunotherapy, aiming to provide new ideas for the development of new targets and peptide inhibitors for T cell immunotherapy.
