Research progress on the antitumor effects of platinum-based chemo-immunotherapies

VernacularTitle:具有抗肿瘤免疫治疗作用的铂类药物研究进展
Author: Feihong CHEN ¹ ; Deming ZHAO ; Shaohua GOU
Author Information

1. 东南大学化学化工学院化学生物学与制药工程系
Publication Type:Journal Article
Keywords: immunomodulators / platinum(II)-based drugs / platinum(IV) complexes / combined drug therapy / chemo-immunotherapy
From: Journal of China Pharmaceutical University 2024;55(1):26-35
CountryChina
Language:Chinese
Abstract: Abstract: As potential immunomodulators, platinum-based drugs could trigger immunogenic cell death (ICD). Hence, combination of platinum-based chemotherapy and immunotherapy could have better synergistic anticancer effect. Pt(II)-based drugs are the most common chemotherapeutic agents in cancer treatment yet with limited clinical application due to their toxic side-effects and drug resistance. Pt(IV) complexes have been widely investigated in the past decades due to their kinetic inertness and unique mechanisms . This article summarizes the progress in the pharmacological activities and mechanisms of Pt(IV) antitumor complexes via introducing different immunomodulators into chemotherapeutic agents in literature over recent years and highlights the potential targets and molecular signaling pathways so as to provide some reference for further development and potential clinical application of platinum-based chemo-immunotherapeutic agents.