Research progress of cGAS-STING signaling pathway modulators in immunotherapy
10.11665/j.issn.1000-5048.2023112402
- VernacularTitle:cGAS-STING信号通路调节剂在免疫治疗中的研究进展
- Author:
Fangning LOU
1
;
Mingyue ZHENG
;
Kaixian CHEN
;
Sulin ZHANG
Author Information
1. 中国药科大学药学院
- Publication Type:Journal Article
- Keywords:
cGAS-STING signaling pathway / STING agonist / cGAS inhibitor / STING inhibitor / immunotherapy
- From:
Journal of China Pharmaceutical University
2024;55(1):15-25
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Upon monitoring cytoplasmic aberrant double-stranded DNA, cGAS-STING signaling pathway induces the expression of type I interferons and pro-inflammatory cytokines, which activates the host immune response and enhances anti-tumor immune response and resistance to pathogen infection. However, sustained activation of the cGAS-STING signaling pathway drives diseases such as autoimmune diseases, aging-associated inflammation, and neurodegenerative pathologies. Herein, we describe the mechanism by which cGAS-STING signaling pathway participates in regulating the development of various immune-related diseases, with a particular review of the research and development progress of STING agonists, cGAS inhibitors, and STING inhibitors, aiming to provide some theoretical reference for the future development of cGAS-STING modulators.
