Double trouble: Establishing synchronous primary tumors of the urothelium and prostate by Immunohistomorphology: A report of two cases
https://doi.org/10.21141/PJP.2020.06
- Author:
David Jerome Ong
1
;
Elizabeth Ann Alcazaren
1
;
Jose Carnate Jr.
1
Author Information
1. Department of Laboratory Medicine and Pathology, The Medical City, Pasig City, Philippines
- Publication Type:Case Reports
- Keywords:
Immunohisotchemistry;
PSA;
Prostatic adenocarcinoma;
Urothelial carcinoma
- From:
Philippine Journal of Pathology
2020;5(1):44-49
- CountryPhilippines
- Language:English
-
Abstract:
Synchronous primary tumors of the urothelium and prostate are a diagnostic challenge among
pathologists. Differentiating carcinomas of urothelial and prostatic origin requires careful assessment of histomorphology coupled with ancillary studies such as immunohistochemistry stains (IHC) to support the diagnosis. We report two cases of adult patients who underwent transurethral resection of the prostate (TURP), with two distinct morphologies noted on routine H&E sections. After a panel of immunohistochemical stains (HMWCK, CK5/6, CK7, CK20, GATA-3, p63, NKX3.1, and PSA), both cases were signed out as papillary urothelial carcinoma and prostatic acinar adenocarcinoma. Correlation of histomorphology with an IHC panel consisting of cytokeratins (CK5/6, CK7, CK20), a urothelial marker (GATA-3), and at least two prostatic markers (PSA, NKX3.1) is recommended in such cases.
- Full text:54 pjp.pdf
