Mixed small cell and large cell neuroendocrine carcinoma involving the endometrium: A case report and literature review
https://doi.org/10.21141/PJP.2021.05
- Author:
Joshua Uyboco
1
;
Mary Anne Cruz-Ignacio
2
;
Maria Concepcion Cenizal
3
;
Jeffrey So
1
;
Maximino Bello III
2
;
Jose Moran
3
Author Information
1. Institute of Pathology, St Lukes Medical Center - Quezon City, Philippines
2. Cancer Institute, St Lukes Medical Center - Quezon City, Philippines
3. Department of Obstetrics and Gynecology, St Lukes Medical Center - Quezon City, Philippines
- Publication Type:Case Reports
- MeSH:
Endometrial Neoplasms;
Carcinoma, Neuroendocrine;
Carcinoma, Large Cell;
Carcinoma, Small Cell
- From:
Philippine Journal of Pathology
2021;6(1):43-49
- CountryPhilippines
- Language:English
-
Abstract:
Neuroendocrine carcinoma (NEC) of the endometrium is a rare, aggressive subtype of endometrial cancer. We report a 61-year-old female with a history of breast cancer, s/p modified radical mastectomy, chemotherapy, radiotherapy and hormonal (tamoxifen) therapy, who presented with post-menopausal bleeding. Patient underwent TAH-BSO with lymph node dissection, and was diagnosed with a mixed small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC), confirmed by positive immunohistochemical staining for neuroendocrine markers. No other lesions were identified on PET-CT, making a primary endometrial NEC the most likely diagnosis. We review the clinical and pathologic characteristics of endometrial neuroendocrine carcinomas.
- Full text:33 pjp.pdf
