Research progress on animal models of combined radiation-wound injury

VernacularTitle:放创复合伤动物模型的研究进展
Author: Ruolin HAO ¹ ; Guifang DOU ¹ ; Zhiyun MENG ¹ ; Tong YE ¹ ; Nanxi LI ¹ ; Xiaoxia ZHU ¹ ; Ruolan GU ¹ ; Zhuona WU ¹ ; Hui GAN ¹
Author Information

1. Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850 China.
Publication Type:ReviewArticles
Keywords: Combined radiation-wound injury; Animal model; Difficult-to-heal wound; Radiation
From: Chinese Journal of Radiological Health 2024;33(2):209-214
CountryChina
Language:Chinese
Abstract: A combined radiation-wound injury refers to a radiation injury combined with a traumatic wound, with the characteristics of repeated ulceration and a long and difficult healing process, which is a focus in the field of research on difficult-to-heal wounds. To research combined radiation-wound injuries, the establishment of animal models is a key part, and appropriate animal models are a guarantee of reliable experimental results. This review summarizes the current research progress on various animal models of combined radiation-wound injuries in terms of radiation types, animal species, and injury types and location, aiming to provide a scientific basis for establishing standardized animal models, studying injury mechanisms, and evaluating prevention and treatment efficacy for combined radiation-wound injuries.