Relationship between zinc finger protein A20, CTGF and FibroScan and fibrosis in chronic hepatitis B patients
10.3969/j.issn.1006-2483.2024.03.031
- VernacularTitle:慢性乙肝患者锌指蛋白A20、CTGF、FibroScan与肝纤维化关系
- Author:
Song ZHANG
1
;
Zilong ZHAO
1
;
Qian HU
1
;
Jian LI
1
;
Xiaojing WANG
1
;
Huijie GENG
1
;
Haiyan KANG
1
;
Dianxing SUN
2
,
3
;
Zhengrong GUO
4
,
5
Author Information
1. Department of Infection Section Six , Shijiazhuang Fifth Hospital , Shijiazhuang , Hebei 050021, China
2. All-Army Liver Disease Treatment Center, Department of Liver Diseases , Ninth 80th Hospital of the People'
3. s Liberation Army , Shijiazhuang , Hebei 050021, China
4. Department of Gastroenterology , Shijiazhuang People'
5. s Hospital , Shijiazhuang , Hebei 050012, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Zinc finger protein A20;
Connective tissue growth factor;
FibroScan;
Liver fibrosis;
Immunohistochemistry
- From:
Journal of Public Health and Preventive Medicine
2024;35(3):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective Studies on the expression and location of zinc finger protein A20 (A20) and connective tissue growth factor (CTGF) in liver tissues of patients with chronic hepatitis B were conducted, and the relationship between them and liver fibrosis was determined by FibroScan. Methods Studies on A20 and CTGF in liver tissues of 160 patients with chronic hepatitis B were conducted in accordance with the stage of pathological fibrosis and inflammation of the liver, and quantitative immunohistochemistry test was conducted, and statistical analysis was conducted by FibroScan. Results The expressions of A20 and CTGF in liver tissues increased with the aggravation of liver pathological fibrosis and inflammation, and there were significant differences between each stage and the control group (P<0.05), and there were significant differences between adjacent groups (P<0.05). Studies have shown that FibroScan increases along with pathological fibrosis and inflammation in the liver. There are significant differences between the stage and the control group (P<0.05), and no significant differences between the adjacent groups (P>0.05). There was positive correlation between liver A20 and CTGF, r=0.796 (P<0.05). Conclusions In patients with chronic hepatitis B, A20, CTGF and FibroScan are positively correlated with the degree of liver fibrosis, and A20 and CTGF are also positively correlated with the degree of liver inflammation, which can be used as indicators to evaluate the degree of liver inflammation and fibrosis, and further guide the anti-inflammatory and anti-fibrosis treatment of patients.
