Clinical risk factors for chronic complications in patients with type 2 diabetes and their correlation with bone mineral density and 1,25-dihydroxyvitamin D3
10.3969/j.issn.1006-2483.2024.03.023
- VernacularTitle:2型糖尿病患者慢性并发症的临床风险因素及与骨密度、1,25-二羟维生素D3的相关性
- Author:
Yunxia LUO
1
,
2
;
Li LIU
3
,
4
,
5
;
Fan YIN
4
,
5
,
6
;
Qing LONG
1
,
2
Author Information
1. Department of General Medicine , Sichuan University West China Guang'
2. an Hospital , Guang'an , Sichuang 638000 , China
3. Department of Respiratory Medicine , Sichuan University West China Guang'
4. an Hospital , Guang'
5. an , Sichuang 638000 , China
6. Department of Gastroenterology , Sichuan University West China Guang'
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Chronic complications;
Bone mineral density;
1,25-dihydroxyvitamin D3
- From:
Journal of Public Health and Preventive Medicine
2024;35(3):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical risk factors for chronic complications in patients with type 2 diabetes and their correlation with bone mineral density and 1,25-dihydroxyvitamin D3. Methods A total of 163 patients with type 2 diabetes mellitus were selected as research subjects and were divided into complication group and non-complication group according to the presence or absence of chronic complications. The independent related factors for chronic complications in patients with type 2 diabetes mellitus were analyzed. Spearman rank correlation analysis was used to evaluate the correlation between bone mineral density, 1,25-dihydroxyvitamin D3 and chronic complications. Results Among the 326 patients with type 2 diabetes mellitus, 202 developed chronic complications (61.96%), including 71 cases of cardiovascular disease, 59 cases of neuropathy, 33 cases of renal lesion, and 28 cases of retinopathy. There were statistically significant differences in the duration of diabetes mellitus, fasting blood glucose, systolic blood pressure, glycosylated hemoglobin, triglyceride, low density lipoprotein cholesterol, serum creatinine, bone mineral density, and 1,25-dihydroxyvitamin D3 between the complication group and the non-complication group (P<0.05). Logistic multivariate regression analysis showed that the duration of diabetes mellitus, systolic blood pressure, glycosylated hemoglobin, ow density lipoprotein cholesterol, serum creatinine, bone mineral density, and 1,25-dihydroxyvitamin D3 were all independent related factors for the occurrence of chronic complications in patients with type 2 diabetes mellitus (P<0.05). Spearman correlation analysis showed that bone mineral density and 1,25-dihydroxyvitamin D3 were negatively correlated with chronic complications (P<0.05). Conclusion Bone mineral density and 1,25-dihydroxyvitamin D3 in patients with type 2 diabetes mellitus are closely related to chronic complications.
