Advances in meningococcal polysaccharide conjugate vaccine research
10.13200/j.cnki.cjb.004186
- VernacularTitle:脑膜炎球菌多糖结合疫苗的研究进展
- Author:
MENG Qingxia
- Publication Type:Journal Article
- Keywords:
Meningococcus;
Polysaccharide conjugate vaccine;
Carrier protein
- From:
Chinese Journal of Biologicals
2024;37(4):370-375
- CountryChina
- Language:Chinese
-
Abstract:
Meningococcal polysaccharide conjugate vaccine is basically produced by chemical combination,and the most commonly used method is amide condensation reaction.Because of the covalent bonds between polysaccharide and protein,the prepared conjugate vaccine has high stability and good technical advantages,which plays an important role in the prevention of meningococcal related diseases.The vaccine can be applied to the immunization of young children under 2years old,and has more lasting protective effect.In this paper,the factors influencing the preparation of meningococcal polysaccharide conjugate vaccine,the binding mode of polysaccharide and carrier protein,the present situation at home and abroad and the existing problems in the preparation process were reviewed.
