Oxidative Stress-related Signaling Pathways in Lung Cancer and Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20240508
- VernacularTitle:氧化应激干预肺癌相关信号通路及中药干预研究进展
- Author:
Anqi LYU
1
;
Yufeng SHI
1
;
Cheng JIANG
2
;
Jia KE
2
Author Information
1. College of Traditional Chinese Medicine（TCM），Hubei University of Chinese Medicine，Wuhan 430060，China
2. Hubei Provincial Hospital of TCM/Affiliated Hospital of Hubei University of Chinese Medicine/Hubei Academy of TCM，Wuhan 430074，China
- Publication Type:Review
- Keywords:
oxidative stress;
lung cancer;
traditional Chinese medicine;
signaling pathways
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(11):228-237
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer has the highest incidence and mortality rate among all cancers in China， with its complex and variable nature， long treatment duration， and often poor prognosis. Currently， the treatment of lung cancer mainly employs classical therapies such as surgery， radiotherapy， and chemotherapy， but some patients may experience a series of adverse reactions， which affect their quality of life， survival period， and treatment outcomes. As reported， oxidative stress is one of the important pathogenic factors of lung cancer， affecting its occurrence and development. Oxidative stress is a state of imbalance between oxidative products and antioxidant defense mechanisms in the body. The intervention of oxidative stress in the occurrence and development of lung cancer is related to multiple signaling pathways， including the Kelch-like ECH-associated protein 1 （Keap1）-nuclear factor erythroid 2-related factor 2 （Nrf2） signaling pathway， phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR） signaling pathway， mitogen-activated protein kinase （MAPK） signaling pathway， and nuclear factor-κB （NF-κB） signaling pathway. Currently， researchers in China and abroad have conducted extensive studies on the occurrence and development of lung cancer and the pathophysiological mechanisms of drug intervention. The results have shown that oxidative stress plays an important role in the occurrence and development of lung cancer. Chinese medicine monomers and compounds can regulate oxidative stress levels and intervene in related signaling pathways， thereby inhibiting or delaying the occurrence and development of lung cancer. Based on this， this article mainly summarized the relevant signaling pathways regulating oxidative stress intervention in lung cancer in recent years， and also reviewed the latest research on Chinese medicine monomers and compounds in regulating oxidative stress to treat lung cancer， aiming to provide new ideas for research on drug treatment of lung cancer and clinical drug development， as well as to provide references and guidance for further in-depth mechanistic studies in the future.
