Extraction Process and Mechanism of Active Ingredients of Mori Folium for Lowering Blood Glucose： A Review
10.13422/j.cnki.syfjx.20240825
- VernacularTitle:桑叶降糖有效部位提取工艺及作用机制研究进展
- Author:
Jiamei XIE
1
;
Huilin ZHANG
1
;
Yan HUANG
2
;
Menglu WANG
1
;
Yuhang DU
1
;
Changhao HE
1
;
Yongcheng AN
1
;
Wanxin FU
2
;
Ziyi SHAN
2
;
Baosheng ZHAO
3
Author Information
1. College of Chinese Materia Medica， Beijing University of Chinese Medicine， Beijing 102488， China
2. College of Life Sciences， Beijing University of Chinese Medicine， Beijing 102488， China
3. Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China
- Publication Type:Journal Article
- Keywords:
Mori Folium;
diabetes mellitus;
lowering blood glucose;
extraction methods;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(11):60-69
- CountryChina
- Language:Chinese
-
Abstract:
Mori Folium， the dried leaves of Morus alba， is widely used in clinical practice for dispersing wind and heat， clearing the lung and moistening dryness， soothing the liver and improving vision， and cooling blood and stopping bleeding. It has been used to regulate blood glucose since ancient times， and modern studies have shown that the active components of Mori Folium for lowering blood glucose mainly include flavonoids， alkaloids， polysaccharides， and phenols. These components are mainly extracted by solvents such as water and alcohols with the assistance of ultrasound and microwave. In addition， new extraction methods are emerging， such as CO2 supercritical fluid extraction， enzymatic hydrolysis， and cloud point extraction. Mori Folium lowers blood glucose via multiple components， pathways， and targets. Specifically， it can improve glucose and lipid metabolism， protect pancreatic β cells， and alleviate insulin resistance to reduce the damage caused by hyperglycemia and restore normal physiological functions. Although a large number of studies have been carried out on diabetes， the causes and radical treatment methods remain to be explored， and diabetes is still a major disease that endangers human health and needs to be solved urgently. The articles about extraction process and mechanism of active components in Mori Folium for lowering blood glucose were retrieved from the China National Knowledge Infrastructure （CNKI）， Web of Science， and PubMed. We analyzed the applicable extraction methods for the blood glucose-lowering components such as flavonoids， polysaccharides， and alkaloids in Mori Folium， and compared the conventional and emerging methods. Furthermore， we summarized our research achievements in the extraction of active components from Mori Folium and the blood glucose-lowering effect and mechanisms. This review aims to provide theoretical support for the optimization of the extraction process， the research on the blood glucose-lowering components and mechanism， and the development of new drugs and clinical application of Mori Folium.
