Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia
10.3971/j.issn.1000-8578.2024.24.0016
- VernacularTitle:靶向T细胞免疫治疗急性髓性白血病的策略
- Author:
Yangqiu LI
1
Author Information
1. Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China
- Publication Type:Research Article
- Keywords:
Acute myeloid leukemia;
T cell;
Exhaustion;
Immune checkpoint protein;
Immunotherapy
- From:
Cancer Research on Prevention and Treatment
2024;51(4):229-233
- CountryChina
- Language:Chinese
-
Abstract:
T cell dysfunction is a common feature in patients with acute myeloid leukemia (AML). The up-regulation of immune checkpoint (IC) proteins resulting in T cell exhaustion is a key reason for T cell dysfunction. Immunotherapy with IC inhibitors exerts a remarkable effect on AML. However, due to the heterogeneity of T cell exhaustion and other factors that impair T cell function in patients with AML, the optimization of targeted T cell immunotherapy strategy for AML might be based on the multidimensional investigation of immune deficiency with different T cell subtypes.
