Systemic Hormonal Unloading (SHU) in secondary hypertension: Addressing the long-term adverse cardiovascular outcomes
10.35460/2546-1621.2024-0044
- Author:
Leilani B. B. Mercado-Asis
1
,
2
;
Felisse Carmen Gomez-Tuazon
2
,
3
;
Florence Rochelle Gan
2
;
Chandy Lou Malong-Calanoc
4
Author Information
1. Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines
2. University of Santo Tomas Hospital, Manila, Philippines
3. Angeles University Foundation and Medical Center, Angeles City, Pampanga, Philippines
4. Nueva Ecija Doctors Hospital, Cabanatuan City, Nueva Ecija, Philippines
- Publication Type:Other Types
- Keywords:
Systemic hormonal unloading;
Secondary hypertension;
Bilateral adrenal venous sampling;
Cardiovascular adverse outcomes
- MeSH:
Hyperaldosteronism;
Pheochromocytoma;
Quality of Life
- From:
Journal of Medicine University of Santo Tomas
2024;8(1):1390-1397
- CountryPhilippines
- Language:English
-
Abstract:
Excess hormone production from adrenal tumors caused by primary hyperaldosteronism or pheochromocytoma are common etiologies for secondary hypertension. Studies have shown that sustained long-term circulating hormones in excess affect the blood vessels and cardiac structures. Inflammation of cardiomyocytes leads to fibrosis and eventual cardiomyopathy and is clinically presented as arrhythmia, nonfatal myocardial infarction, heart failure, or even death. The tissue changes and/or impaired cardiac function are reversible if early diagnosis and removal of the adrenal tumor by unilateral adrenalectomy is done. However, the condition becomes challenging if the adrenal lesions are bilateral. This article introduces the concept of systemic hormonal unloading and will discuss the philosophy of quality of life in managing bilateral adrenal disease.
- Full text:jmust 11.pdf
