Research progress on the mechanism of traditional Chinese medicine intervening in esophageal cancer by microRNA regulation
- VernacularTitle:中药调节微RNA干预食管癌的机制研究进展
- Author:
Zhiwen SHEN
1
;
Liqun LI
2
;
Mingyao XU
1
;
Xin LIU
1
;
Jing HUANG
1
;
Xiaoning ZHANG
1
;
Jiaqi YIN
1
;
Sheng XIE
2
Author Information
1. Graduate School，Guangxi University of Chinese Medicine，Nanning 530200，China
2. Dept. Two of Spleen and Stomach Diseases，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
esophageal cancer;
microRNA;
signaling pathway;
target genes
- From:
China Pharmacy
2024;35(8):1016-1022
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer （EC） is a common malignant tumor of the digestive system with an extremely poor prognosis. MicroRNA （miRNA） is an important regulator in tumor occurrence and development， and can participate in malignant biological behaviors such as tumor cell proliferation， invasion， metastasis and apoptosis. Traditional Chinese medicine has the characteristics of accurate curative effects， wide range of effects， and few side effects. The review uses miRNA as the entry point to systematically elaborate on the mechanism of traditional Chinese medicine-mediated miRNA intervening in EC. The results showed that active ingredients of traditional Chinese medicine （including curcumin， Tussilago farfara polysaccharides， Atractylodes macrocephala polysaccharides and ophiopogonin B） and Dougen guanshitong oral liquid could up-regulate the expressions of miRNAs such as miRNA-532-3p （miR-532-3p）， miR-551b-3p， miR-99a， miR-34a， miR-199a-3p and miR-377； and the active ingredients/parts of traditional Chinese medicine （including chrysin and Actinidia arguta extract）， and Chinese herbal formulas （including Chaihu shugan san combined with Xuanfu daizhe decoction and Modified jupi zhuru decoction） could down-regulate the expressions of miRNAs such as miR-199a-3p， miR-451 and miR-21， which could regulate the expressions of signaling pathways （phosphoinositide 3-kinase/protein kinase B， etc.） or their downstream protein（zinc-finger and homeobox protein 1， etc.） or enzymes（thymidine kinase-1， etc.）， inhibit the proliferation， invasion and metastasis of EC cells and induce apoptosis， thereby ultimately achieving the purpose of preventing the disease from aggravating.
