Three 2,3-diketoquinoxaline alkaloids with hepatoprotective activity from Heterosmilax yunnanensis
10.16438/j.0513-4870.2023-1218
- VernacularTitle:短柱肖菝葜中的3个2,3-二酮喹喔啉类生物碱及其肝保护活性
- Author:
Rong-rong DU
1
;
Xin-yi GUO
1
;
Wen-jie QIN
2
;
Hua SUN
1
;
Xiu-mei DUAN
2
;
Xiang YUAN
1
;
Ya-nan YANG
1
;
Kun LI
3
;
Pei-cheng ZHANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Beijing Zhendong Guangming Pharmaceutical Research Institute, Beijing 100085, China
3. Shanxi Zhendong Pharmaceutical Co. Ltd., Changzhi 047100, China
- Publication Type:Research Article
- Keywords:
italic>Heterosmilax yunnanensis;
Liliaceae;
2,3-diketoquinoxaline;
hepatoprotective activity
- From:
Acta Pharmaceutica Sinica
2024;59(2):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Three 2,3-diketoquinoxaline alkaloids were isolated from Heterosmilax yunnanensis Gagnep. Their structures were determined through 1D and 2D NMR, HR-ESI-MS, UV, and IR as 1-[5′-(3″-hydroxy-3″-methyl) glutaryl] ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (1), 1-[2′-(3″-hydroxy-3″-methyl) glutaryl]ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (2), and 1-ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (3). Compounds 1 and 2 are novel compounds, and 3 was isolated from H. yunnanensis for the first time. The hepatoprotective activity of these three compounds was evaluated, with compound 3 showing promising hepatoprotective activity.
