Recent advances in drug screening methods of SARS-CoV-2 spike protein
10.16438/j.0513-4870.2023-0507
- VernacularTitle:SARS-CoV-2刺突蛋白抑制剂活性筛选方法研究进展
- Author:
Li-de HU
;
Chuan-feng LIU
;
Ping LI
;
Guan-yu DONG
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
coronavirus;
SARS-CoV-2;
spike protein;
rug screen;
rug discovery
- From:
Acta Pharmaceutica Sinica
2024;58(2):298-312
- CountryChina
- Language:Chinese
-
Abstract:
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious impact on global public health and the economy. SARS-CoV-2 infiltrates host cells via its surface spike protein, which binds to angiotensin-converting enzyme 2 on the host cell membrane. As a result, small molecules targeting spike protein have emerged as a hotspot in anti-SARS-CoV-2 drug research. Activity screening is an important step in seeking small molecule drugs. Therefore, this article aims to review the biological activity evaluation methods of small molecule inhibitors targeting SARS-CoV-2 spike protein, with the goal of laying the foundation for the discovery of new anti-SARS-CoV-2 drugs.
