Advances in methods and techniques for the study of polysaccharide in vivo processes and immunomodulatory mechanisms
10.16438/j.0513-4870.2023-0473
- VernacularTitle:多糖体内过程与免疫调节机制研究方法和技术进展
- Author:
Chi-yun ZHU
;
Ping XIAO
;
Yue-yue FANG
;
Meng-ting LAI
;
Jin-ao DUAN
- Publication Type:Research Article
- Keywords:
polysaccharide;
pharmacokinetics;
immunomodulation;
mechanism of action;
new technology
- From:
Acta Pharmaceutica Sinica
2024;58(2):322-335
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, polysaccharides have received much attention because of their high safety and good immunological activity. The study of polysaccharide in vivo process is a key scientific problem that needs to be solved for polysaccharide drug development. Some progress has been made in the field of polysaccharide pharmacokinetics and immunomodulation. However, due to the lack of both chromogenic and light-absorbing groups and the complex molecular structure of polysaccharides, the in vivo processes and immunomodulatory mechanisms of polysaccharides have been slow to be investigated. The effective combination of multiple techniques can break the bottleneck of difficult tracing and unknown immunomodulatory mechanism of polysaccharides in vivo, and promote the development and utilization of polysaccharides. In this paper, we systematically summarize the key techniques in the study of polysaccharide in vivo processes and immunomodulatory mechanisms in order to provide technical references and research ideas for the study of polysaccharide in vivo processes and immunomodulatory mechanisms.
