Recent progress on the effects of structured lipids and fluidity of plasma membrane on tumor metastasis
10.16438/j.0513-4870.2023-1271
- VernacularTitle:细胞膜结构脂质与膜流动性影响肿瘤侵袭转移的研究进展
- Author:
Lin LI
- Publication Type:Research Article
- Keywords:
plasma membrane;
membrane lipid;
lipid raft;
membrane fluidity;
tumor metastasis
- From:
Acta Pharmaceutica Sinica
2024;59(3):520-531
- CountryChina
- Language:Chinese
-
Abstract:
The lipid composition of cell plasma membranes of aggressive tumors is significantly altered from normal, affecting the membrane fluidity and function. Plasma membrane fluidity involves multiple steps in tumor invasion and metastasis, including cell movement, adhesion, lateral diffusion of membrane molecules, signal transduction, material exchange and so on. This review highlights the difference in plasma membrane lipid composition and fluidity between normal and cancer cells, as well as the correlation with the invasion and metastasis potential of cancer. We also point out that the proliferation, invasion and metastasis of tumors can be inhibited by improving membrane fluidity or interfering with the membrane structured lipid composition, this focusing more on changing the biophysical properties of cancer cell membranes, and providing a novel strategy that works for treatment of tumor metastasis.
