The mechanism of chlorogenic acid against neuropathic pain induced by cisplatin
10.16438/j.0513-4870.2023-1120
- VernacularTitle:绿原酸拮抗顺铂诱发的神经病理性疼痛的机制研究
- Author:
Na LI
1
;
Xue-hui ZHANG
2
Author Information
1. Department of Pharmacy, Xinxiang Central Hospital (the Fourth Clinical College, Xinxiang Medical College), Xinxiang 453000, China
2. Department of Pharmacy, the Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou 215228, China
- Publication Type:Research Article
- Keywords:
chlorogenic acid;
cisplatin;
chemotherapy-induced pain;
orsal root ganglion;
transient receptor potential vanilloid type-1
- From:
Acta Pharmaceutica Sinica
2024;59(3):616-620
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to investigate the analgesic effect of chlorogenic acid on cisplatin-induced neuropathic pain and explored the underlying molecular mechanisms. The animal experimental protocol has been reviewed and approved by Laboratory Animal Ethics Committee of Xinxiang Central Hospital, in compliance with the Institutional Animal Care Guidelines. Von Frey hair and a radiant heat was employed to measure mechanical allodynia and thermal hyperalgesia; Western blot was used to examine transient receptor potential vanilloid type-1 (TRPV1) protein expression in the rat dorsal root ganglion (DRG); patch clamp was used to record TRPV1 currents in DRG neurons. The experimental results showed that chlorogenic acid could attenuate cisplatin-induce mechanical allodynia and thermal hyperalgesia in rats. The expression of TRPV1 protein in DRGs was increased in cisplatin-treated rats, while chlorogenic acid also could reverse cisplatin-induced the upregulation of TRPV1 protein. Forthermore, chlorogenic acid could attenuate cisplatin-mediated the upregulation of TRPV1 current density. These above results indicated that chlorogenic acid could alleviate cisplatin-induced pain hypersensitivity through inhibition of the expression and function of TRPV1 in rats.
