Two new flavonoid glycosides from <italic>Diphylleia sinensi</italic>

Hao-jie WANG; Chen ZHAO; Yan-jun SUN; Jian-hong GONG; Hong-yun BAI; Hui CHEN; Wei-sheng FENG

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Two new flavonoid glycosides from Diphylleia sinensi

VernacularTitle:窝儿七中2个新的黄酮苷类化合物
Author: Hao-jie WANG ^{1
,

2
,

3
,

4} ; Chen ZHAO ^{1
,

2} ; Yan-jun SUN ^{1
,

2
,

3
,

4} ; Jian-hong GONG ^{4
,

5} ; Hong-yun BAI ^{4
,

5} ; Hui CHEN ^{4
,

5} ; Wei-sheng FENG ^{1
,

2
,

4}
Author Information

1. Henan University of Chinese Medicine, Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan &
2. Education Ministry of China, Zhengzhou 450046, China
3. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
4. Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
5. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
Publication Type:Research Article
Keywords: italic>Diphylleia sinensi; chemical constituent; flavonoid glycoside; extraction and isolation; italic>Diphylleia
From: Acta Pharmaceutica Sinica 2024;59(3):673-677
CountryChina
Language:Chinese
Abstract: Five flavonoid glycosides were isolated from the methanol and ethyl acetate fractions of the ethanol extract of Diphylleia sinensi by using various chromatographic methods, including silica gel, MCI gel, Sephadex LH-20, ODS and semi-preparative HPLC. The structures of the isolated compounds were identified as diphyflavonoid A (1), diphyflavonoid B (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4), kaempferol-3-O-(6″-O-acetyl)-β-D-glucopyranoside (5) by spectroscopy methods (1D NMR, 2D NMR, UV, IR, and MS). Compounds 1 and 2 were two new flavonoid glycosides, and compounds 3 and 5 were isolated from the genus Diphylleia for the first time.