The role of glucose metabolism reprogramming and its targeted therapeutic agents in inflammation-related diseases
10.16438/j.0513-4870.2023-0993
- VernacularTitle:糖代谢重编程及其靶向治疗药物在炎症相关疾病中的作用
- Author:
Yi WEI
1
;
Xiao-man JIANG
1
;
Shi-lin XIA
1
;
Jing XU
1
;
Ya LI
1
;
Ran DENG
2
;
Yan WANG
1
;
Hong WU
1
Author Information
1. Key Lab of Xin′an Medicine, Ministry of Education, Anhui Province Key Laboratory of Research and Development of Chinese Medicine, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
- Publication Type:Research Article
- Keywords:
glucose metabolism reprogramming;
aerobic glycolysis;
inflammation-related disease;
inflammatory microenvironment;
targeted therapy
- From:
Acta Pharmaceutica Sinica
2024;58(3):511-519
- CountryChina
- Language:Chinese
-
Abstract:
Cells undergo glucose metabolism reprogramming under the influence of the inflammatory microenvironment, changing their primary mode of energy supply from oxidative phosphorylation to aerobic glycolysis. This process is involved in all stages of inflammation-related diseases development. Glucose metabolism reprogramming not only changes the metabolic pattern of individual cells, but also disrupts the metabolic homeostasis of the body microenvironment, which further promotes aerobic glycolysis and provides favourable conditions for the malignant progression of inflammation-related diseases. The metabolic enzymes, transporter proteins, and metabolites of aerobic glycolysis are all key signalling molecules, and drugs can inhibit aerobic glycolysis by targeting these specific key molecules to exert therapeutic effects. This paper reviews the impact of glucose metabolism reprogramming on the development of inflammation-related diseases such as inflammation-related tumours, rheumatoid arthritis and Alzheimer's disease, and the therapeutic effects of drugs targeting glucose metabolism reprogramming on these diseases.
