Research progress of needle-free injection technology
10.16438/j.0513-4870.2023-0853
- VernacularTitle:无针注射技术的研究进展
- Author:
He ZHANG
1
,
2
;
Shuo LI
3
;
Yi CHENG
1
;
Zeng-ming WANG
1
;
Nan LIU
1
;
Meng LI
1
;
Hui ZHANG
1
;
Ai-ping ZHENG
1
Author Information
1. China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
2. Department of Pharmacy, The 909th Hospital/ Dongnan Hospital of Xiamen University, Zhangzhou 363000, China
3. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
- Publication Type:Research Article
- Keywords:
needle-free injection technology;
needle-free jet injector;
rug delivery system;
pressure source;
vaccine
- From:
Acta Pharmaceutica Sinica
2024;59(3):591-599
- CountryChina
- Language:Chinese
-
Abstract:
Needle-free injection technology (NFIT) refers to the drug delivery systems in which drugs are propelled as high-speed jet streams using any of the pressure source to penetrate the skin to the required depth. NFIT is a promising drug delivery system as it enables the injection of liquids, powders, and depot/projectiles, and has the advantages of preventing needle stick accidents, improving drug bioavailability, eliminating needle-phobia, increasing vaccine immunity, simplifying operations and is convenient for patients to use. NFIT and its research background, the structure and classification of needle-free jet injectors (NFJI), drugs that can be delivered using NFJI and the factors affecting the injection effect are comprehensively reviewed in this paper. The limitations and potential development directions are summarized to provide a theoretical basis for the application and development of NFIT.
