Biosensor analysis technology and its research progress in drug development of Alzheimer's disease
10.16438/j.0513-4870.2023-0818
- VernacularTitle:生物传感器分析技术及其在阿尔茨海默病药物研发中的研究进展
- Author:
Shu-qi SHEN
1
;
Jia-hao FANG
1
;
Hui WANG
1
;
Liang CHAO
1
;
Piao-xue YOU
2
;
Zhan-ying HONG
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, China
2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
- Publication Type:Research Article
- Keywords:
Alzheimer's disease;
biosensor;
surface plasmon resonance;
biolayer interferometry;
fluorescence analysis technology;
rug screening
- From:
Acta Pharmaceutica Sinica
2024;59(3):554-564
- CountryChina
- Language:Chinese
-
Abstract:
Biosensor analysis technology is a kind of technology with high specificity that can convert biological reactions into optical and electrical signals. In the development of drugs for Alzheimer's disease (AD), according to different disease hypotheses and targets, this technology plays an important role in confirming targets and screening active compounds. This paper briefly describes the pathogenesis of AD and the current situation of therapeutic drugs, introduces three biosensor analysis techniques commonly used in the discovery of AD drugs, such as surface plasmon resonance (SPR), biolayer interferometry (BLI) and fluorescence analysis technology, explains its basic principle and application progress, and summarizes their advantages and limitations respectively.
