Drugs that act in the lymphatic system and lymphatic drug delivery: review and perspective
10.16438/j.0513-4870.2023-0814
- VernacularTitle:基于淋巴系统的药物及其递送系统研究进展
- Author:
Luo-juan HU
1
;
Jing-kai GU
2
;
Qi-dong YOU
1
,
3
;
Si-fei HAN
1
,
3
,
4
Author Information
1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
2. Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun 130012, China
3. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
4. Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne VIC
- Publication Type:Research Article
- Keywords:
lymphatic system;
lymphatic drug delivery;
immunotherapy;
pharmacokinetics of macromolecules;
nanomedicine
- From:
Acta Pharmaceutica Sinica
2024;59(3):565-573
- CountryChina
- Language:Chinese
-
Abstract:
The lymphatic system, as well as pathological changes of the lymphatic system, underlies the progress of an array of diseases and conditions, including cancer, inflammation and autoimmune disorders, infectious diseases and metabolic syndrome. A variety of biological targets in the lymphatic system can be employed to modulate these high-burden diseases, and the pharmacokinetics and drug delivery strategies in the context of lymphatics are of critical importance to optimise drug exposure to lymphatic-related targets. As such, research and drug development in this field has gained increasing attention in recent years. This article aims to provide an overview of pharmaceutical research with a focus on the lymphatic system and therapeutic targets within the lymphatics, followed by lymphatic drug delivery approaches, which may be of interest for researchers in academia, pharmaceutical industry and regulatory sciences.
