Research progress of natural product evodiamine-based antitumor drug design strategies
10.16438/j.0513-4870.2023-0764
- VernacularTitle:以天然产物吴茱萸碱为先导结构的抗肿瘤药物设计策略研究进展
- Author:
Zhe-wei XIA
;
Yu-hang SUN
;
Tian-le HUANG
;
Hua SUN
;
Yu-ping CHEN
;
Chun-quan SHENG
;
Shan-chao WU
- Publication Type:Research Article
- Keywords:
natural product;
evodiamine;
rug design;
structural optimization;
antitumor
- From:
Acta Pharmaceutica Sinica
2024;59(3):532-542
- CountryChina
- Language:Chinese
-
Abstract:
Natural products are important sources for the discovery of anti-tumor drugs. Evodiamine is the main alkaloid component of the traditional Chinese herb Wu-Chu-Yu, and it has weak antitumor activity. In recent years, a number of highly active antitumor candidates have been discovered with a significant progress. This article reviews the research progress of evodiamine-based antitumor drug design strategies, in order to provide reference for the development of new drugs with natural products as leads.
