Research progress of Mendelian randomization in ocular diseases
10.3980/j.issn.1672-5123.2024.5.23
- VernacularTitle:孟德尔随机化在常见眼病中的研究进展
- Author:
Xiran ZHANG
1
;
Weichen YUAN
1
;
Xiangrui LI
1
;
Feier XU
1
;
Fangkun ZHAO
1
Author Information
1. China Medical University, Shenyang 110122, Liaoning Province, China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
ocular diseases;
etiological study;
causality
- From:
International Eye Science
2024;24(5):784-789
- CountryChina
- Language:Chinese
-
Abstract:
Etiological research is necessary for understanding the occurrence and epidemiological patterns of diseases, and is also a prerequisite for the diagnosis, prevention and treatment of clinical diseases. Mendelian randomization(MR), a method of research that combines genetics and epidemiology, has the advantage of exploring the causal relationship between exposure and disease genetically as well as avoiding confounding factors and reverse causation. Thus, it has been extensively utilized in the etiological study of diseases. This paper reviews the implementation of MR in the research of ocular diseases and provides ideas and approaches for the investigation of related mechanisms as well as the development of intervention strategies.
