Research progress of biological agents in thyroid-associated ophthalmopathy
10.3980/j.issn.1672-5123.2024.5.21
- VernacularTitle:生物制剂在甲状腺相关眼病中的研究进展
- Author:
Jingxiao ZHAO
1
;
Ping WANG
1
;
Minmin JIANG
1
;
Shuxun YAN
1
Author Information
1. The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
- Publication Type:Journal Article
- Keywords:
thyroid-associated ophthalmopathy;
biological agents;
monoclonal antibodies;
targeted therapy;
drug therapy
- From:
International Eye Science
2024;24(5):772-777
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-associated ophthalmopathy(TAO)is a rare organ-specific autoimmune disease with an unclear pathogenesis. At present, the treatment still relies mainly on glucocorticoids and traditional immunosuppressants. However, some patients respond poorly to these drugs and experience treatment-related adverse reactions, highlighting the urgent need for novel drugs for TAO treatment. In recent years, with the deepening of research on the pathogenesis of TAO, a multitude of biologics targeting specific targets have emerged. Among them, teprotumumab, which targets the insulin-like growth factor-I receptor(IGF-IR), has been approved by the Food and Drug Administration for the treatment of TAO, and several other biologics are currently in clinical trials. This review provides the latest reference for the clinical prevention, treatment, and research of TAO by summarizing the current clinical research status of biologics targeting IGF-IR, neonatal Fc receptor(FcRn), thyroid-stimulating hormone receptor(TSHR), B cells, cytokines, and other biological agents in TAO and analyzing their impact on clinical treatment and future research trends.
