Research progress of B lymphocytes in non-infectious uveitis
10.3980/j.issn.1672-5123.2024.5.10
- VernacularTitle:B细胞在非感染性葡萄膜炎中的研究进展
- Author:
Yuanyuan YANG
1
;
Zhiruo WANG
1
;
Gong CHEN
1
;
Huihui CHEN
1
Author Information
1. Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
- Publication Type:Journal Article
- Keywords:
B cell;
non-infectious uveitis;
immune imbalance;
antibodies;
antigen presentation;
cytokines;
Rituximab
- From:
International Eye Science
2024;24(5):718-722
- CountryChina
- Language:Chinese
-
Abstract:
Non-infectious uveitis, an autoimmune disease that can cause severe visual impairment, can be difficult to treat. According to the prevailing hypothesis, the immune-mediated imbalance that contributes to non-infectious uveitis is primarily driven by CD4+T cells. However, recent research has shown that B cells also play a significant role in this process, participating in various ways such as antibody production, antigen presentation, and cytokine secretion in both human uveitis and experimental autoimmune uveitis models. Therapies targeting B cells have been used extensively in various autoimmune diseases. Rituximab, a B-cell inhibitor, is effective in treating noninfectious uveitis that is unresponsive to conventional corticosteroid and immunosuppressive therapy. This paper provides an overview of the involvement of B cells in non-infectious uveitis and their potential use in cellular therapies, aiming to further investigate the mechanisms and develop more effective strategies for prevention and treatment.
