Comparison of intravitreal injection of Ranibizumab versus Conbercept in the treatment of retinopathy of prematurity

Juan Chen; Yunqi Zhang; Suzhen Xie; Jianbing Ren; Jing LI; Chuan Nie; Zhijiang Liang; Qizhen HE; Xuelin Huang; Xianqiong Luo

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Comparison of intravitreal injection of Ranibizumab versus Conbercept in the treatment of retinopathy of prematurity

VernacularTitle:玻璃体腔注射雷珠单抗与康柏西普治疗早产儿视网膜病变疗效比较
Author: Juan CHEN ^{1
,

2} ; Yunqi ZHANG ^{1
,

2} ; Suzhen XIE ^{1
,

2} ; Jianbing REN ^{1
,

2} ; Jing LI ^{1
,

2} ; Chuan NIE ^{1
,

2} ; Zhijiang LIANG ^{1
,

2} ; Qizhen HE ^{1
,

2} ; Xuelin HUANG ^{1
,

2} ; Xianqiong LUO ^{1
,

2}
Author Information

1. Guangdong Medical University, Guangzhou 511495, Guangdong Province, China
2. Department of Neonatology
Publication Type:Journal Article
Keywords: retinopathy of prematurity; Ranibizumab; Conbercept; efficacy
From: International Eye Science 2024;24(5):697-703
CountryChina
Language:Chinese
Abstract: AIM: To compare the efficacy of intravitreal injection of ranibizumab(IVR)and intravitreal injection of conbercept(IVC)in children with retinopathy of prematurity(ROP).METHODS: Retrospective study. A total of 1 100 eyes with ROP treated with intravitreal anti-VEGF at our hospital from January 2015 to June 2023 were included. According to the different therapeutic drugs, the children were divided into two groups: IVR group and IVC group. According to the degree of ROP, the patients were divided into three groups: aggressive ROP(A-ROP), Zone Ⅰ type 1 ROP and Zone Ⅱ type 1 ROP. The reactivation and retreatment between the two groups were compared after propensity score matching(PSM)analysis, and they were followed-up for at least 3 mo after surgery.RESULTS: In Zone Ⅱ type 1 ROP, there was a statistically significant difference in the rates of reactivation and retreatment between the IVR and IVC groups(P<0.05); however, in A-ROP and Zone I type 1 ROP, there were no statistically significant differences in the rates of reactivation and retreatment between the two groups(P>0.05). The risk of reactivation and retreatment of Zone I type 1 ROP was higher than the Zone II type 1 ROP. Furthermore, the use of drugs and corrected gestational age of first treatment were influencing factors of lesion recurrence and retreatment.CONCLUSION: There is a significant difference in the initial cure effect between the two drugs in Zone II type 1 ROP, with the reactivation and retreatment rates of the IVC group being much lower than those of the IVR group.