Relationship between plasma SP-A expression level and disease stage in silicosis patients
10.19428/j.cnki.sjpm.2024.23202
- VernacularTitle:矽肺患者血浆肺表面活性蛋白A表达与病情分期的关系
- Author:
Kengkeng CHEN
1
;
Bizhu ZHANG
1
;
Yingyi PENG
1
;
Zhifang LIU
1
;
Xiaoyan CHEN
1
;
Jiachun JIN
1
Author Information
1. Department of Occupational Medical Laboratory and Health Monitoring， Guangdong Provincial Institute of Occupational Disease Prevention and Control， Guangzhou， Guangdong 510300， China
- Publication Type:Journal Article
- Keywords:
silicosis;
biomarker;
lung surfactant protein⁃A;
disease stage
- From:
Shanghai Journal of Preventive Medicine
2024;36(2):203-206
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between plasma surfactant protein⁃A （SP⁃A） expression level and silicosis progression， and to provide early evidence for exploring whether SP⁃A can be used as a biomarker for clinical monitoring of silicosis disease progression. MethodsWe recruited 187 silicosis patients in Guangdong Province hospital for occupational disease prevention and treatment between November， 2019 and November，2020. Their peripheral venous blood samples were collected for the plasma isolation. The level of pulmonary SP⁃A was detected by enzyme-linked immunosorbent assay. ResultsThere was a statistically significant difference in the level of SP⁃A among the silicosis groups （P<0.05）， and the plasma SP-A level of the silicosis patients in stage Ⅲ was higher than that in stage Ⅰ and stage Ⅱ （P<0.05）. Smoking had effect on plasma SP⁃A levels， Age， working years and drinking had no effect on plasma SP⁃A levels. ConclusionThe expression level of SP⁃A in the plasma of silicosis patients is increased， which has a certain correlation with the disease stage， and plays a certain early warning role in the occurrence and development of silicosis， and may be a potential biomarker for the diagnosis and prognosis of silicosis.
