Severity of COVID-19 reinfection among healthcare workers in a grade A tertiary hospital in Shanghai by the end of 2022
10.19428/j.cnki.sjpm.2024.23082
- VernacularTitle:2022年末上海某三甲医院工作人员新型冠状病毒感染再感染的严重程度研究
- Author:
Wanwan LIU
1
;
Qiuqiong DENG
1
;
Jianhua MI
1
;
Jingli GU
1
;
Ling YU
1
;
Zhuyi HUANG
1
;
Jiahong ZHAO
1
;
Fei CHEN
1
;
Qin CAO
1
;
Qun XU
1
Author Information
1. Department of Health Management Center， Renji Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200127，China
- Publication Type:Journal Article
- Keywords:
COVID-19;
epidemic characteristic;
reinfection;
primary infection;
healthcare worker
- From:
Shanghai Journal of Preventive Medicine
2024;36(2):123-127
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo describe the epidemic characteristics of COVID-19 after policy adjustment from “Category B notifiable disease with category A management” to “Category B notifiable disease with category B management”， and to explore the protective effect of previous infection with SARS-CoV-2 on common symptoms of reinfection. MethodsHealthcare workers infected with SARS-CoV-2 in a grade A tertiary hospital in Shanghai were included in the study from December 4， 2022 to January 11， 2023. Data on demographic characteristics， clinical symptoms， medical history， and COVID-19 vaccination history were collected. We determined the epidemiological curve and characteristics， and then compared the difference in the severity of clinical symptoms between primary and reinfection subjects. ResultsA total of 2 704 cases were included in the study， of which 45 had reinfection， 605 （22.4%）were males， 608 （22.5%）were doctors， 1 275 （47.2%） were nurses， and 2 351 （86.9%） received ≥3 doses of COVID-19 vaccination. The average age of these healthcare workers was （34.9±9.1） years old. The number of cases with mild/moderate illness， asymptomatic infection， fever， headache， dry cough， expectoration， and chest tightness were 2 704 （100.0%）， 92 （3.4%）， 2 385 （88.2%）， 2 066 （76.4%）， 1 642 （60.7%）， 1 807 （66.8%）， and 439 （16.2%）， respectively. Reinfection was a protective factor for fever （OR=0.161， P<0.001）， headache （OR=0.320， P<0.001）， and peak body temperature （β=-0.446， P<0.001）. ConclusionFollowing the COVID-19 policy adjustment as a category B notifiable disease， healthcare workers at a grade A tertiary hospital in Shanghai predominantly experiences mild to moderate COVID-19 symptoms. Reinfection results in milder clinical manifestations， with a lower proportion of being asymptomatic.
