Mechanism of action of macrophage efferocytosis in acute and chronic liver diseases and related targeted therapy
- VernacularTitle:巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗
- Author:
Huanhuan YANG
1
;
Shiyu YUAN
1
;
Yingmei TANG
1
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Macrophages; Efferocytosis
- From: Journal of Clinical Hepatology 2024;40(4):839-843
- CountryChina
- Language:Chinese
- Abstract: Efferocytosis refers to the process by which apoptotic cells are engulfed and cleared by phagocytes， including professional phagocytes， such as macrophages and dendritic cells， and non-professional phagocytes， such as epithelial cells. Liver macrophages are the main cells with the function of efferocytosis in the liver. In recent years， an increasing number of studies have shown that various acute and chronic liver diseases are associated with the efferocytosis function of liver macrophages， including acute liver injury， alcoholic liver disease， nonalcoholic fatty liver disease， autoimmune liver disease， liver fibrosis， and liver cancer. This article elaborates on the expression of molecules associated with the efferocytosis function of macrophages， the process of efferocytosis， and the role of efferocytosis function in different liver diseases， so as to provide new ideas for the treatment of liver diseases.
