Pathogenesis of hepatitis B-associated intrahepatic cholangiocarcinoma
- VernacularTitle:乙型肝炎相关肝内胆管癌的发病机制
- Author:
Qiyu TIAN
1
;
Jian YU
2
;
Gang HUANG
2
Author Information
- Publication Type:Review
- Keywords: Cholangiocarcinoma; Hepatitis B virus; Carcinogenesis
- From: Journal of Clinical Hepatology 2024;40(4):797-803
- CountryChina
- Language:Chinese
- Abstract: Intrahepatic cholangiocarcinoma （ICC） is a type of primary liver cancer that accounts for about 10% — 15% of the total cases， and its incidence and mortality rates tend to increase significantly around the world， especially in Asian countries. At present， radical liver resection is the only possible cure for ICC， but with a fairly high postoperative recurrence rate and a poorer prognosis than hepatocellular carcinoma. Therefore， it is urgently needed to further investigate the mechanisms of the development and progression of ICC and search for more effective treatment methods. Some epidemiological data suggest that chronic hepatitis B virus infection is one of the most important predisposing factors for ICC， yet little is known about its oncogenic effects. This article summarizes the epidemiological evidence that links the two diseases and briefly elaborates on the mechanisms of the development and progression of HBV-associated ICC， so as to help to gain a better understanding of the role of HBV in the development and progression of ICC.
