Effects of hypoxia-inducible factors on tumor mesenchymal cells: a review

Author: ZHAO Qiwei ; ZHOU Xinyue ; LIU Xiayang ; LI Zhuang ; GUO Xiaohong
Publication Type:Journal Article
Keywords: hypoxia inducible factor; tumor microenvironment; mesenchymal cell; targeted therapy
From: Journal of Preventive Medicine 2024;36(1):34-38
CountryChina
Language:Chinese
Abstract: Hypoxia is the most common tumor microenvironment caused by rapid proliferation of tumor cells, and hypoxia-inducible factor (HIF) is the main transcription factor for tumor cells to adapt to hypoxia. Current research has found that HIF can interact with a variety of mesenchymal cells such as fibroblasts, endothelial cells and immune cells in the tumor microenvironment, leading to the transcription and expression of target genes in response to hypoxia, which ultimately promotes tumor angiogenesis, and induces physiological changes such as migration, invasion, and immune escape of tumor cells. However, the signaling pathways involved in the HIF regulatory mechanism are complex, and the mechanism of HIF in the tumor microenvironment need to be further investigated, also most HIF inhibitors are still in the preclinical research stage. This paper reviews the research progress on the effects of HIF on tumor mesenchymal stromal cells to provide a theoretical basis for the diagnosis, prevention and treatment of tumors targeting HIF.
Full text:缺氧诱导因子对肿瘤间质细胞影响的研究进展.pdf