Pathogenesis of Idiopathic Pulmonary Fibrosis and Modulating Effect of Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241191
- VernacularTitle:特发性肺纤维化的发病机制及中药调节作用研究进展
- Author:
Enguo ZOU
1
;
Tianyu HUANG
1
;
Mulan WANG
1
;
Chenliang ZHA
2
;
Qin GONG
1
;
Weifeng ZHU
1
;
Yulin FENG
1
;
Liangji LIU
3
;
Jun LI
1
Author Information
1. Jiangxi University of Chinese Medicine，Nanchang 330006，China
2. National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine， Jiangxi University of Chinese Medicine，Nanchang 330006，China
3. The Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330006，China
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis （IPF）;
pathogenesis;
Chinese medicine;
mechanism;
macrophage polarization;
epithelial-mesenchymal transition （EMT）;
oxidative stress;
autophagy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(10):280-289
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis （IPF）， as a progressive lung disease， has a poor prognosis and no reliable and effective therapies. IPF is mainly treated by organ transplantation and administration of chemical drugs， which are ineffective and induce side effects， failing to meet the clinical needs. Therefore， developing safer and more effective drugs has become an urgent task， which necessitates clear understanding of the pathogenesis of IPF. The available studies about the pathogenesis of IPF mainly focus on macrophage polarization， epithelial-mesenchymal transition （EMT）， oxidative stress， and autophagy， while few studies systematically explain the principles and links of the pathogeneses. According to the traditional Chinese medicine theory， Qi deficiency and blood stasis and Qi-Yang deficiency are the key pathogeneses of IPF. Therefore， the Chinese medicines or compound prescriptions with the effects of replenishing Qi and activating blood， warming Yang and tonifying Qi， and eliminating stasis and resolving phlegm are often used to treat IPF. Modern pharmacological studies have shown that such medicines play a positive role in inhibiting macrophage polarization， restoring redox balance， inhibiting EMT， and regulating cell autophagy. However， few studies report how Chinese medicines regulate the pathways in the treatment of IPF. By reviewing the latest articles in this field， we elaborate on the pathogenesis of IPF and provide a comprehensive overview of the mechanism of the active ingredients or compound prescriptions of Chinese medicines in regulating IPF. Combining the pathogenesis of IPF with the modulating effects of Chinese medicines， we focus on exploring systemic treatment options for IPF， with a view to providing new ideas for the in-depth study of IPF and the research and development of related drugs.
