Role of Flavonoids in Traditional Chinese Medicine to Improve Cerebral Ischaemia-reperfusion Injury and Its Mechanism： A Review
10.13422/j.cnki.syfjx.20240502
- VernacularTitle:中药黄酮类化合物改善脑缺血再灌注损伤的作用及其机制研究进展
- Author:
Lu YUE
1
;
Tianbao ZHOU
1
;
Xiangli YAN
2
;
Mingsan MIAO
2
;
Yan LI
3
;
Ming BAI
2
Author Information
1. College of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Academy of Traditional Chinese Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
flavonoids in traditional Chinese medicine;
cerebral ischaemia-reperfusion injury;
anti-inflammatory;
antioxidant;
apoptosis inhibition
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(10):269-279
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-reperfusion injury （CIRI） has a very high incidence， disability， and mortality rates， which seriously affects human life and health. In recent years， modern medicine has made some progress in the diagnosis and treatment of CIRI， but there are still problems such as difficulties in postoperative rehabilitation and adverse drug reactions， and new therapeutic drugs for CIRI are urgently needed. As an important class of active ingredients in traditional Chinese medicine， flavonoids can play antioxidant， apoptosis inhibition， anti-inflammatory， and other pharmacological effects to improve brain tissue damage， which is important for improving the quality of life of CIRI patients and slowing down the aging of the social population. Numerous studies have found that flavonoids in traditional Chinese medicine can regulate cell surface receptors Toll-like receptor 4/nuclear factor-kappaB （TLR4/NF-κB）， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， adenylate-activated protein kinase/mammalian target of rapamycin protein （AMPK/mTOR）， Ras homologous gene family member A/Rho-associated coiled-coil protein kinase （RhoA/ROCK）， nuclear factor E2-associated factor 2/Kelch-like epoxychloropropane-associated protein-1/haemoglobin oxygenase 1 （Nrf2/Keap1/ HO-1）， Notch， and other signaling pathways， so as to regulate the transcription and expression of related proteins after CIRI， alleviate brain tissue injury， and improve CIRI. This paper analyzed the relevant literature in China and abroad in recent years， reviewed the mechanism of action and related pathways of flavonoids in traditional Chinese medicine to improve CIRI， and explored the new therapeutic direction of CIRI at the metabolic level， with a view to providing a basis for the further development and application of flavonoids in traditional Chinese medicine.
